Search on: NITRIC OXIDE-SENSITIVE GUANYLYL CYCLASE 
Descriptors Found: 1
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Descriptor English:   Soluble Guanylyl Cyclase 
Descriptor Spanish:   Guanilil Ciclasa Soluble 
Descriptor Portuguese:   Guanilil Ciclase Solúvel 
Synonyms English:   Cyclase, Soluble Guanylate
Cyclase, Soluble Guanylyl
Guanylate Cyclase, Soluble
Guanylyl Cyclase, Soluble
Nitric Oxide Receptor
Nitric Oxide Receptors
Nitric Oxide Sensitive Guanylyl Cyclase
Nitric Oxide-Sensitive Guanylyl Cyclase
Oxide Receptor, Nitric
Oxide Receptors, Nitric
Receptor, Nitric Oxide
Soluble Guanylate Cyclase
Soluble Guanylyl Cyclase, alpha Subunit
Soluble Guanylyl Cyclase, beta Subunit  
Tree Number:   D08.811.520.650.600.750
D12.644.360.350.500
D12.776.476.350.500
Definition English:   A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals. 
History Note English:   2017 (2016) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   56499 
Unique Identifier:   D000071756 

Occurrence in VHL: 		 

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